ISIS Neutron and Muon Source Data Journal

Effect of aggregation states of A?42-Monomer and Fibril on the Dynamics of a Neuronal Model Membrane

Abstract: Amyloid A? (1-42), A?42 is predominantly found in the form of plaques in the brain tissues in Alzheimer's disease. Studies have shown that A?42 plaques are mainly responsible for cognitive dysfunctionality in Alzheimer?s. A?42 exist in different aggregation states namely monomer (M), ?-sheets, oligomer (O), or fibril (F). Studies have shown that the incorporation of amyloid, depending upon the amino acid length and aggregation states, can affect the phospholipid membrane distinctively. This can lead to structural and dynamic changes in the membrane and hence can affect membrane functions. Therefore, it is essential to investigate the effect of the aggregation states of A?42 on the dynamics and physiological relevant neuronal phospholipid membrane extracted from mammalian brain tissues on the picosecond time scale. This study can be useful to understand amyloid membrane interaction and add to our understanding of Alzheimer's disease. Here, we wish to investigate the effect of aggregation states of human A?42, a neurotoxic peptide, monomer (M) and fibril (F) on the dynamics of neuronal phospholipid membrane extracted from mammalian brain tissues

Local Contact: Dr Mona Sarter
Experimenter: Dr Victoria Garcia Sakai
Experimenter: Dr Sebastian Jaksch
Experimenter: Dr Olaf Holderer
Experimenter: Dr Purushottam Dubey
Experimenter: Mr Henrich Frielinghaus
Experimenter: Dr Veerendra K Sharma
Local Contact: Dr Sanghamitra Mukhopadhyay

DOI: 10.5286/ISIS.E.RB2310176

ISIS Experiment Number: RB2310176

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Mona Sarter et al; (2025): Effect of aggregation states of A?42-Monomer and Fibril on the Dynamics of a Neuronal Model Membrane, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2310176

Data is released under the CC-BY-4.0 license.