ISIS Neutron and Muon Source Data Journal

Thermal cross sections of hydrogels for NMR-driven neutron capture therapy

Abstract: We propose a neutron experiment to establish and validate a quantitative procedure whereby information from nuclear magnetic resonance (NMR) spectroscopy and imaging is used to provide patient-specific neutron scattering libraries to be used to optimize transport codes in neutron capture therapy. In particular, using chemical shift spectra from 1H-NMR, the idea is to reconstruct the relative concentrations of organic functional groups in standard samples, and use these data to build the sample-specific macroscopic cross section at thermal neutron energies using the Average Functional Group Approximation. Therefore, we propose a neutron transmission measurement, taking advantage of the broad range of incident neutron energies available on the VESUVIO spectrometer, on a series of well-characterized hydrogel systems composed of semi-interpenetrated polymer networks (SIPN) to be suggested and used as standards for both neutron scattering and NMR standards.

Experimenter: Professor Carla Andreani
Experimenter: Professor Roberto Senesi
Experimenter: Professor Giovanni Romanelli
Experimenter: Professor Emiliano Fratini
Local Contact: Dr Matthew Krzystyniak
Experimenter: Dr Enrico Preziosi
Experimenter: Mr Matteo Castellani
Experimenter: Ms Margherita Simoni
Experimenter: Mr Riccardo Bizzi
Experimenter: Miss Seila Addessi
Experimenter: Dr Sara Notari
Experimenter: Student Elena Tomei

DOI: 10.5286/ISIS.E.RB2310166

ISIS Experiment Number: RB2310166

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Carla Andreani et al; (2023): Thermal cross sections of hydrogels for NMR-driven neutron capture therapy, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2310166

Data is released under the CC-BY-4.0 license.