ISIS Neutron and Muon Source Data Journal

Understanding the role of antimicrobial polymer topology as driver for selective disruption of bacterial plasma membranes

Abstract: This proposal aims to get information on the action mechanism of a novel class of antimicrobial polymers (APs) towards model bacterial membranes. It is well known that antimicrobial resistance is an increasingly serious threat to public global health. A possible solution to this issue is the development of antimicrobial substances that are not susceptible toward resistance development. APs are promising candidates in this context as their mechanism of action (the disruption of bacterial membranes) does not cause bacterial resistance. Some of us have recently synthesized some APs with different molecular architectures and have proofed their efficacy against phospholipid-bilayers mimicking bacterial membranes. To get insights about the processes occurring at the polymer-phospholipid interface, we propose to perform a systematic investigation with neutron reflectometry, as detailed in the proposal text.

Experimenter: Mr Alain Murhimalika Bapolisi
Experimenter: Dr Gaetano Mangiapia
Experimenter: Dr Jean-François Moulin
Local Contact: Dr Stephen Hall
Experimenter: Dr Matthias Hartlieb
Experimenter: Dr Rainhard Machatschek

DOI: 10.5286/ISIS.E.RB2310211

ISIS Experiment Number: RB2310211

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Mr Alain Murhimalika Bapolisi et al; (2023): Understanding the role of antimicrobial polymer topology as driver for selective disruption of bacterial plasma membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2310211

Data is released under the CC-BY-4.0 license.