ISIS Neutron and Muon Source Data Journal

Identification of the collapse mechanism of responsive block copolymer brushes for controlled gene delivery

Abstract: Dense polymer brushes have exceptional potential to regulate the sequestration of RNA/DNA materials for high efficiency gene transfection. Polycationic brushes decorating the surface of nanoparticles have promising properties for the stable capture of RNA oligonucleotides and high transfection efficiencies. A new generation of such vectors proposes to use block copolymer brushes to mimic compartmentalised hierarchical virus structures. However, control of responsive block copolymer brushes? architecture remains poor at the nanoscale. This proposal?s objective is to resolve the thickness-dependent morphological changes (domain/homogenous barrier formation) of amphiphilic block copolymer brushes grown from solid (Si) substrates. It will contribute to the confirmation and refinement of existing computational modelling studies and to the elucidation of their properties for gene delivery.

Principal Investigator: Dr Ali Zarbakhsh
Experimenter: Professor Julien Gautrot
Local Contact: Dr Mario Campana

DOI: 10.5286/ISIS.E.RB2220109

ISIS Experiment Number: RB2220109

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Ali Zarbakhsh et al; (2023): Identification of the collapse mechanism of responsive block copolymer brushes for controlled gene delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220109

Data is released under the CC-BY-4.0 license.