ISIS Neutron and Muon Source Data Journal

Structure and Evaluation of Nanodrug Hydrogel Delivery Systems for Psoriasis Treatment using Rheo-SANS

Abstract: The experiments will evaluate and optimise a novel smart controlled release injectable liposomal hydrogel drug delivery systems from low cost precursors, Pluronic F-127 and chitosan. The matrix?s sol-gel phase transition in the body allows them to be administered as drug loaded solutions before transforming to soft gel depots at body temperature, then release the drug over a designed time. liposomes structural similarity to cells allows for enhanced drugs bioavailability and increased blood circulation time. The proposed systems are designed to regulate the release of Secukinumab® for the treatment of plaque Psoriasis, aiming to reduce cost, dosing frequency and enhance patients? compliance. The requested beamtime will allow us to investigate the effects of combined shear and extensional flow as experienced during real bodily administration on the system's morphology and stability.

Principal Investigator: Dr Bana Shriky
Experimenter: Professor Tim Gough
Experimenter: Dr Maksims Babenko
Local Contact: Dr James Doutch
Local Contact: Dr Najet Mahmoudi

DOI: 10.5286/ISIS.E.RB2220594

ISIS Experiment Number: RB2220594

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Bana Shriky et al; (2023): Structure and Evaluation of Nanodrug Hydrogel Delivery Systems for Psoriasis Treatment using Rheo-SANS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220594

Data is released under the CC-BY-4.0 license.