ISIS Neutron and Muon Source Data Journal

Interaction of lyotropic liquid crystalline nanoparticles suitable for drug delivery with model membranes of different fluidity

Abstract: Lipid-based lyotropic liquid crystalline nanoparticle dispersions, such as hexosomes and cubosomes, are biocompatible vehicles for drug delivery due to their ability to encapsulate lipophilic and hydrophilic molecules. However, the molecular mechanism underlying the cellular uptake of these highly ordered LCNPs is still unclear. Understanding the surface interaction of the hexagonal or cubic phase with lipid membranes could provide important hints for fine-tuning drug delivery. Among cell membrane properties, cholesterol-regulated fluidity could play an important role in the passive uptake of LCNPs. Here, we propose to study the interfacial interaction between hexosomes and cubosomes and model membrane of different fluidity by neutron reflectivity.

Principal Investigator: Dr Michela Pisani
Experimenter: Dr Paola Astolfi
Local Contact: Dr Mario Campana
Experimenter: Dr Silvia Dante

DOI: 10.5286/ISIS.E.RB2220789

ISIS Experiment Number: RB2220789

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Michela Pisani et al; (2023): Interaction of lyotropic liquid crystalline nanoparticles suitable for drug delivery with model membranes of different fluidity, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220789

Data is released under the CC-BY-4.0 license.