ISIS Neutron and Muon Source Data Journal

Polyphosphoester Gradient Co-Polymer Micelles as the First Biodegradable Agents for 31P Magnetic Resonance Imaging

Abstract: Magnetic Resonance Imaging is a powerful medical imaging modality that can provide information on anatomic and molecular level without the use of dangerous ionizing radiation. Hot-spot MRI uses different nuclei than proton. This type of MRI turned out highly efficient for applications where quantification of the imaging agent is important, particularly in imaging cardiovascular diseases, cancer and immunotherapies. However, current hot spot agents are non-biodegradable and show major environmental concerns. As a solution, we have developed the first biocompatible and biodegradable imaging agents for hot spot MRI. These agents are based on polymeric colloids. The structure-function relationship is unknown but is crucial for the future application. We will use SANS to study the structural properties of these agents, and correlate them to imaging performance.

Principal Investigator: Dr Olga Koshkina
Experimenter: Mr Timo Rheinberger
Experimenter: Professor Frederik Wurm
Local Contact: Dr Najet Mahmoudi

DOI: 10.5286/ISIS.E.RB2220573

ISIS Experiment Number: RB2220573

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Olga Koshkina et al; (2023): Polyphosphoester Gradient Co-Polymer Micelles as the First Biodegradable Agents for 31P Magnetic Resonance Imaging, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220573

Data is released under the CC-BY-4.0 license.