ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Structural characterization of hybrid calciprotein nanoparticles
Abstract: Calciprotein particles (CPPs) represent a key defence mechanism of our organism for the prevention of ectopic calcifications. They consist of amorphous calcium phosphate nanospheres stabilized by the glycoprotein Fetuin-A (Fet-A). The study of the protein component in these hybrid mineral-organic nanostructures is crucial to shed light on Fet-A and other serum proteins action mechanism and to develop strategies to stabilize such CPPs, thus preventing their crystallization and precipitation that can result in vascular calcifications. To this purpose, SANS is particularly well-suited as it allows investigating the structural features of the organic components of the hybrid nanoparticles: the characterization of the protein layer around the inorganic core will contribute to unravel how their stabilizing action takes place, giving useful insights into their important physiological role.
Principal Investigator: Dr Rita Gelli
Experimenter: Professor Francesca Ridi
Local Contact: Dr James Doutch
DOI: 10.5286/ISIS.E.RB2220258
ISIS Experiment Number: RB2220258
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2220258-1 | ZOOM | 01 December 2025 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Rita Gelli et al; (2022): Structural characterization of hybrid calciprotein nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220258
Data is released under the CC-BY-4.0 license.
