ISIS Neutron and Muon Source Data Journal

Molecular exchange kinetics of coacervates consisting of antimicrobial peptides and block copolymers monitored by TR-SANS

Abstract: Antimicrobial peptides (AMPs) are not yet readily suitable for systemic delivery in therapeutic applications, as they have low retainability, are degraded, and are cytotoxic. This project aims to find and define systems to effectively encapsulate AMPs with block copolymers, through complex coacervation, to reduce the side effects of AMP treatment. In complex coacervation, controlled phase separation is induced by interactions between oppositely charged macromolecules. In the proposed experiment we aim to understand the stability of these nanoparticles by studying the molecular exchange kinetics. In this way, by determining the rate of which the molecules move in and out of the assemblies, we can correlate the effective exposure of the peptides with biological activity.

Principal Investigator: Professor Reidar Lund
Local Contact: Dr James Doutch
Experimenter: Mr Thomas Vogelaar
Experimenter: Professor håvard jenssen
Experimenter: Mr Vladimir Koynarev

DOI: 10.5286/ISIS.E.RB2220505

ISIS Experiment Number: RB2220505

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Reidar Lund et al; (2022): Molecular exchange kinetics of coacervates consisting of antimicrobial peptides and block copolymers monitored by TR-SANS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220505

Data is released under the CC-BY-4.0 license.