ISIS Neutron and Muon Source Data Journal

SANS Study of Membrane Disruptions by Rationally Designed Cationic Lipopeptides

Abstract: A group of designed lipopeptides with only 4 amino acids have displayed large differences in antimicrobial efficacy against E. coli and biocompatibility, as well as in secondary structures upon membrane binding. SANS is about the only method that could help reveal how these lipopeptides attack inner and outer bacterial membranes from the established SUV membrane models for Gram-negative bacteria. This work is part of PhD research by Tianhao Ge and constitutes an important aspect of our design and development of effective antimicrobial peptides. 3 days of beam time is requested on SANS2D. SANS2D is preferred because of the need for high resolution and coverage of the entire Q range due to the different size range, requiring measurement over 3 angles to cover the q-range from 0.001 to 0.4 Å-1.

Principal Investigator: Professor Jian Lu
Experimenter: Mr kangcheng shen
Experimenter: Dr Xuzhi Hu
Experimenter: Mr Zeyuan ZHUANG
Experimenter: Dr Arwel Hughes
Local Contact: Dr Steve King
Experimenter: Miss Anna Stephens
Experimenter: Dr Mingrui Liao
Experimenter: Miss Caroline Ding
Experimenter: Miss Tianhao Ge

DOI: 10.5286/ISIS.E.RB2220153

ISIS Experiment Number: RB2220153

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2022): SANS Study of Membrane Disruptions by Rationally Designed Cationic Lipopeptides, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220153

Data is released under the CC-BY-4.0 license.