ISIS Neutron and Muon Source Data Journal

Stealth properties of nanoparticles decorated with poly-N-(2-hydroxypropyl)methacrylamide studied by SANS contrast variation

Abstract: Mucus is a viscoelastic gel present on various moist surfaces of human body including gastrointestinal tract, eyes, respiratory system, bladder and vagina. Administration of drugs via mucosal membranes offers a number of advantages as it can be used as an alternative to injections and sometimes gives an opportunity to deliver medication directly to the target organ. However, the mucus gel often acts as a barrier for successful drug delivery; it can trap drug molecules before they are able to reach surface cells and achieve therapeutic effects. The aim of this research is to develop and characterise nanoparticles, whose surface is decorated with a polymer water-soluble polymer coating. This coating will provide these nanoparticles an ability to penetrate through the mucus.

Principal Investigator: Professor Vitaliy Khutoryanskiy
Experimenter: Dr Mahmoud Abu Elella
Experimenter: Professor Sergej Filippov
Local Contact: Dr Steve King

DOI: 10.5286/ISIS.E.RB2220213

ISIS Experiment Number: RB2220213

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Vitaliy Khutoryanskiy et al; (2022): Stealth properties of nanoparticles decorated with poly-N-(2-hydroxypropyl)methacrylamide studied by SANS contrast variation, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220213

Data is released under the CC-BY-4.0 license.