ISIS Neutron and Muon Source Data Journal

Structural Accommodation of Microbubbles into Protein Hydrogel Network

Abstract: Our vision is to address a major challenge in healthcare. By embedding drug-loaded microbubbles(MBs) within folded protein hydrogels we aim to control the release of therapeutic drug molecules.MBs can be burst, via the application of ultrasound, releasing the loaded drugs and allowing theirfree diffusion from the hydrogel at the desired time. In Leeds we have completed acharacterisation of the structure and mechanics of the system across length scales using proteinengineering, spectroscopy, rheology and modelling. Here, for the first time, we aim to examine thestructure of MBs embedded within protein hydrogels, allowing for the completion of multiscaleexamination of this multi-composite system. Such insight is vital for the further development of thissystem towards drug delivery applications.

Principal Investigator: Professor Lorna Dougan
Experimenter: Dr Matthew Hughes
Experimenter: Miss Sophie Cussons
Local Contact: Dr Najet Mahmoudi
Experimenter: Miss Christa Brown

DOI: 10.5286/ISIS.E.RB2220731

ISIS Experiment Number: RB2220731

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Lorna Dougan et al; (2022): Structural Accommodation of Microbubbles into Protein Hydrogel Network, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220731

Data is released under the CC-BY-4.0 license.