ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Understanding the structure of novel RNA-Lipid nanoparticles using SANS
Abstract: The recent Covid-19 pandemic has shown both the efficacy and need to develop effective vaccines and drug delivery. One technology which has been very effective at this uses lipid nanoparticles. These are small particles in which the lipid layer allows us to target the immune system. The nanoparticles are used to deliver a dose of mRNA. The exact dose held depends upon the encapsulation properties of the nanoparticle. We propose using SANS to look at the properties of a novel lipid nanoparticle system to determine how this system is able to encpsulate a high degree of mRNA and also remain very stable over a long period of time, contrary to other systems which require freezing.
Principal Investigator: Dr Rene van Nostrum
Experimenter: Dr Steven Parnell
Local Contact: Dr Gregory Smith
Experimenter: Mr Lucas Czentner Colomo
DOI: 10.5286/ISIS.E.RB2269000
ISIS Experiment Number: RB2269000
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2269000-1 | LARMOR | 22 July 2025 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Rene van Nostrum et al; (2022): Understanding the structure of novel RNA-Lipid nanoparticles using SANS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2269000
Data is released under the CC-BY-4.0 license.
