ISIS Neutron and Muon Source Data Journal

Understanding the encapsulation and release of drugs by responsive supramolecular cyclic peptide nanotubes

Abstract: Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling intolong nanotubes. The conjugation of hydrophilic and hydrophobic polymers to these peptides leads to self-assembly of ?tubisomes?, supramolecular assemblies of nanotubes. We have demonstrated that hydrophobic drugs, such as doxorubicin (a common chemotherapy agent), can be encapsulated within tubisomes. We have engineered photo-responsiveness into these tubisomes, such that the particles disassemble upon exposure to UV light to release their therapeutic cargo. Here, we propose to use SANS to understand the chemical factors which influence the capacity of these materials to encapsulate drugs and their morphology in solution, and understand the disassembly mechanism upon exposure to UV light. This will enable the optimised design of controlled, tuneable tubisomes as drug delivery vectors.

Principal Investigator: Professor Sebastien Perrier
Local Contact: Dr Gregory Smith
Experimenter: Miss Maria Kariuki
Experimenter: Dr Stephen Hall
Experimenter: Miss Sophie Hill
Experimenter: Miss Cathy CHENG
Experimenter: Dr Min Zeng
Experimenter: Ms Lena Dalal
Experimenter: Mr Vito Kontrimas
Experimenter: Mrs Matilde Concilio
Experimenter: Dr Julia Rho

DOI: 10.5286/ISIS.E.RB2210302

ISIS Experiment Number: RB2210302

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Sebastien Perrier et al; (2022): Understanding the encapsulation and release of drugs by responsive supramolecular cyclic peptide nanotubes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210302

Data is released under the CC-BY-4.0 license.