ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
The orientation of RIT1 on tethered bilayer lipid membranes using neutron reflectivity.
Abstract: Rit1 is a signaling protein whose orientation at the membrane is vital for a mechanistic understanding of human cancer. Neutron reflectometry (NR) is among the few techniques that can structurally characterize this protein under physiologically relevant biomimetic conditions at the lipid membrane. We will conduct a series of NR measurements with increasing concentrations of Rit1 using a model membrane, which will characterize the conformation of the protein at the membrane as a function of crowding. This work is a direct continuation of our recent research on the functionally related KRAS protein (Van, Q. N. et al. Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane. Proc National Acad Sci 117, 24258?24268 (2020)).
Principal Investigator: Dr Frank Heinrich
Local Contact: Dr Luke Clifton
DOI: 10.5286/ISIS.E.RB2210123
ISIS Experiment Number: RB2210123
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2210123-1 | OFFSPEC | 16 July 2025 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Frank Heinrich et al; (2022): The orientation of RIT1 on tethered bilayer lipid membranes using neutron reflectivity., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210123
Data is released under the CC-BY-4.0 license.
