ISIS Neutron and Muon Source Data Journal

Effect of phospholipid tail length and saturation on the spontaneous vesicle formation in the presence of amphiphilic drugs

Abstract: Biological membranes and their interactions are naturally of the utmost importance for all living entities. Amphiphilic drugs interact and self-assemble with phospholipids and are expected to influence properties related to pharmacological activity and toxicity. For instance, they are expected to play a crucial role regarding specific interactions with receptor proteins, hemolytic degradation, as well as function as a drug delivery agent in release mechanisms and transport of drug molecules across cell membranes. The main purpose of the experiment is to determine the influence of the phospholipid tail length on the spontaneous vesicle formation in presence of amphiphilic drugs. The other key objective is determining the distribution of the drug in spontaneously formed drug/phospholipid vesicles by means of employing hydrated as well as a deuterated phospholipid in a contrast match study.

Principal Investigator: Dr Lars Magnus Angantyr Bergström
Local Contact: Dr James Doutch
Experimenter: Mr Vahid Forooqi Motlaq

DOI: 10.5286/ISIS.E.RB2210079

ISIS Experiment Number: RB2210079

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Lars Magnus Angantyr Bergström et al; (2022): Effect of phospholipid tail length and saturation on the spontaneous vesicle formation in the presence of amphiphilic drugs, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210079

Data is released under the CC-BY-4.0 license.