ISIS Neutron and Muon Source Data Journal

Structural investigation on a new family of amorphous calcium ortho- and pyro-phosphates materials for bone substitution

Abstract: Amorphous calcium phosphates have been extensively studied as bioactive bone substitute materials thanks to the biocompatibility and bioactivity of calcium orthophosphate phases. A few studies on calcium pyrophosphate biomaterials have demonstrated their promising biological properties through cell and animal studies and a clinical trial. Recently, we demonstrated the possibility to associate both ortho- and pyro-phosphates in the same amorphous material and the capability of this new family of materials to degrade and lead apatite formation in different acellular media. We propose to perform neutron diffraction with isotopic substitution experiments (in complement of X-ray experiments) and to determine the short range order around H and Ca atoms, which could allow us to solve the structure of these new amorphous materials that is crucial to predict their in vivo behaviour.

Principal Investigator: Dr Capucine SASSOYE
Experimenter: Dr Gabriel Cuello
Experimenter: Dr Jeremy Soulié
Experimenter: Professor Christèle Combes
Local Contact: Dr Tristan Youngs

DOI: 10.5286/ISIS.E.RB2210101

ISIS Experiment Number: RB2210101

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Capucine SASSOYE et al; (2022): Structural investigation on a new family of amorphous calcium ortho- and pyro-phosphates materials for bone substitution, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210101

Data is released under the CC-BY-4.0 license.