ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Molecular interactions in the two-component system of the accessory gene regulator of Staphylococcus aureus
Abstract: Two component systems are common response mechanism to extracellular stimuli in bacteria. Sensory element activation triggers ATP-dependent autophosphorylation and the recruitment of a downstream response mediating transcription factor. We propose to study the association between soluble catalytic domain from the accessory gene regulator in S. aureus, AgrC, and its downstream response partner, AgrA, responsible for modulation of virulence and collective bacterial behaviour. Deuterated components will be characterised in the presence of ATP or non-hydrolysable ATP analogues and the assembly of the complex will be monitored by SANS.
Principal Investigator: Professor Boyan Bonev
Local Contact: Dr James Doutch
Experimenter: Miss Sara Zandomeneghi
DOI: 10.5286/ISIS.E.RB2210355
ISIS Experiment Number: RB2210355
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2210355-1 | ZOOM | 13 May 2025 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Boyan Bonev et al; (2022): Molecular interactions in the two-component system of the accessory gene regulator of Staphylococcus aureus, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210355
Data is released under the CC-BY-4.0 license.
