ISIS Neutron and Muon Source Data Journal

Bacterial membrane rupture dynamics and mechanism by bio-degradable Gemini surfactants

Abstract: Bio-degradable Gemini surfactants are dimeric surfactants incorporating hydrolysable moieties into their hydrophobic constituents. Their greater antimicrobial efficacy compared to monomeric analogues creates potential for industrial formulation in personal care products. However, their interactions with the bacterial membrane are not well understood. In collaboration with P&G, the world?s largest personal care product manufacturer, we propose using small angle neutron scattering (SANS) to investigate the changes in morphology of bacteria-mimicking liposomes comprised of DDPE, DPPG and cardiolipin upon surfactant binding. The results will provide mechanistic details of the interactions between these novel biodegradable Gemini surfactants and membranes, guiding their future rational molecular design.

Principal Investigator: Professor Wuge Briscoe
Experimenter: Dr Binglei song
Experimenter: Miss Xueying Guo
Experimenter: Mr Oliver McDowell
Experimenter: Dr Robert Dalgliesh
Experimenter: Miss Holly Stockdale
Experimenter: Dr Eric Robles
Local Contact: Dr Sarah Rogers

DOI: 10.5286/ISIS.E.RB2210057

ISIS Experiment Number: RB2210057

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Wuge Briscoe et al; (2022): Bacterial membrane rupture dynamics and mechanism by bio-degradable Gemini surfactants, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210057

Data is released under the CC-BY-4.0 license.