ISIS Neutron and Muon Source Data Journal

Interactions between biocidal surfactants and bacterial membrane mimics: a NR study at the air-water interface

Abstract: Quaternary ammonium compounds (QACs) have high inhibitory and bactericidal activity against pathogenic microbes and their toxicity has been found to depend upon their structure. However, no simple correlation has been reported. QAC surfactants are thought to interact with cell membranes through association of the positively charged quaternary nitrogen with the polar headgroups of some phospholipids. The hydrophobic tails of the surfactants subsequently interact with the hydrophobic region of the lipid bilayer. Insertion into the membrane can affect the structure and physical properties of the membrane, such as curvature, surface charge and lateral pressure, undermining the functioning of membrane proteins. The aim of this work is to determine how membrane structure changes with QAC biocide binding.

Principal Investigator: Professor Jian Lu
Experimenter: Dr Xuzhi Hu
Experimenter: Dr Laura Fox
Experimenter: Miss Anna Stephens
Experimenter: Miss Tianhao Ge
Experimenter: Professor Jordan Petkov
Experimenter: Dr Zongyi Li
Experimenter: Miss Caroline Ding
Local Contact: Dr Maxmilian Skoda

DOI: 10.5286/ISIS.E.RB2210113

ISIS Experiment Number: RB2210113

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2022): Interactions between biocidal surfactants and bacterial membrane mimics: a NR study at the air-water interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210113

Data is released under the CC-BY-4.0 license.