ISIS Neutron and Muon Source Data Journal

Endosomal Interaction of Lipid Nanoparticles

Abstract: There has been a shift in the pharmaceutical industry's focus towards development of therapeutic molecules that act at specific sub-cellular compartments, thereby creating a demand for advanced delivery vehicles that convey their payload to the required site of action. A common feature of intracellular delivery is that the delivery vehicle is taken up by the target cells via endocytosis with the vehicle becoming engulfed in the endosome. In order for the therapeutic molecule to exert its action, it must escape from the endosome. Neutron reflectometry will help to unravel the interaction(s) between the lipid nanoparticles, carrying nucleic acid, of interest here and the endosomal membranes (and in particular the early stage endosomal membranes) to enable the design of efficient delivery vehicles that can escape the endosome at an early stage with an intact nucleic acid payload.

Experimenter: Dr Dave Barlow
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Richard Campbell
Experimenter: Ms Marina Efstratiou
Experimenter: Professor Jayne Lawrence
Experimenter: Dr Alice Spadea
Experimenter: Mr Samuel Winnall

DOI: 10.5286/ISIS.E.RB2210326

ISIS Experiment Number: RB2210326

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Dave Barlow et al; (2022): Endosomal Interaction of Lipid Nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210326

Data is released under the CC-BY-4.0 license.