ISIS Neutron and Muon Source Data Journal

New insight into interactions of statins with lipid monolayers

Abstract: Statins are commonly administered to reduce cholesterol. Drug-lipid interactions determine the passive transport of drugs through membranes, yet work is required to elucidate the structure-function relationship of series of statins. Here we build on recent work comparing interactions of pravastatin, fluvastatin and simvastatin (different hydrophobicity) with DMPS and DMPC lipid monolayers (different charge). We learned in a recent neutron reflectometry experiment a great depth of information about relative squeeze out of these drugs with changing surface pressure, as well as prolonged interactions of simvastatin. However, our structural dataset is incomplete, and we do not know is pravastatin rearranges to avoid squeeze out with DMPC or if there is an extended structure for simvastatin with DMPS. The proposed additional measurements will allow us to complete this study for publication.

Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Dorota Matyszewska
Experimenter: Miss Michalina Zaborowska
Experimenter: Dr Glenn Coope
Experimenter: Dr Richard Campbell

DOI: 10.5286/ISIS.E.RB2210135

ISIS Experiment Number: RB2210135

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maxmilian Skoda et al; (2022): New insight into interactions of statins with lipid monolayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210135

Data is released under the CC-BY-4.0 license.