ISIS Neutron and Muon Source Data Journal

Using an epithelial model membrane to investigate polyphenol-lipid interactions with neutron reflectometry

Abstract: The epithelium, the outermost surface of the gastrointestinal mucosal layer of the gut wall, is responsible for digestion, absorption and secretion of materials in the gastrointestinal tract (GIT). The layer is complex and its composition depends on the function of the GIT region. There are many gaps in our knowledge of how the gut wall functions including the role of some of the epithelial cells present, and there is little understanding of the role of the lipid within these cell membranes. We know that lipid composition varies in different areas of the cell membrane, but we know little about how lipids can promote or inhibit interactions or protection of this essential interface. In this project we aim to develop a model epithelium layer that will enable us to investigate the role of different lipid components of the cell membrane and how they impact on the function of the gut wall.

Principal Investigator: Professor Rebecca Green
Local Contact: Dr Luke Clifton
Experimenter: Professor Richard Frazier
Experimenter: Mr Ryan Coones

DOI: 10.5286/ISIS.E.RB2210334

ISIS Experiment Number: RB2210334

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Rebecca Green et al; (2022): Using an epithelial model membrane to investigate polyphenol-lipid interactions with neutron reflectometry, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2210334

Data is released under the CC-BY-4.0 license.