ISIS Neutron and Muon Source Data Journal

Novel lubricating microgel-reinforced hydrogel as a saliva substitute

Abstract: Xerostomia (dry mouth condition resulting from a reduction/absence of saliva) affects at least 1 in 10 adults. Inspired by human saliva, we have designed and filed a patent application for a brand-new, super-lubricious colloidal formulation, composed of a proteinaceous microgel-reinforced biopolymeric hydrogel, which offers substantially enhanced and sustained lubrication - a key benefit making it unique over saliva substitutes currently available on the market for dry mouth sufferers. Preliminary structural studies suggest that the lubricant formulation is composed of spherical microgel particles, which are surrounded by a shell of hydrogel nanofibrils adsorbed on their surface. Now, we would like to use SANS to gain further insight into the molecular structure (size and shape) of our colloidal system, whose knowledge is fundamental to optimising its lubrication performance.

Principal Investigator: Dr Olivia Pabois
Experimenter: Dr Sarah Rogers
Experimenter: Dr Arwen Tyler
Local Contact: Dr James Doutch

DOI: 10.5286/ISIS.E.RB2000279

ISIS Experiment Number: RB2000279

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Olivia Pabois et al; (2021): Novel lubricating microgel-reinforced hydrogel as a saliva substitute, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2000279

Data is released under the CC-BY-4.0 license.