ISIS Neutron and Muon Source Data Journal

Peptides in a glassy matrix at ambient temperature: Relevance for Anhydrobiosis

Abstract: Anhydrobiosis, the possibility of life in almost no water, is a puzzling phenomena common to a wide class of organisms, ranging from plant seeds to crustacean cysts, that can survive to an almost complete removal of intracellular water and restore their metabolic activities when water is newly available. Central to anhydrobiosis is the ability to maintain a functional protein configuration in the dry state. A detailed description on how this is obtained is still lacking, but there is evidence that carbohydrates, such as trehalose, protect protein structure. Aim of this proposal is to investigate the role of trehalose as a bio-protectant, looking at its interaction with two model peptides in presence of residual water molecules at an atomistic level. To this goal, experiments, augmented by computer modelling, on peptide/water/trehalose mixtures at ambient temperature will be performed.

Principal Investigator: Professor Fabio Bruni
Experimenter: Professor Maria Antonietta Ricci
Local Contact: Dr Oliver Alderman
Experimenter: Dr Michael Di Gioacchino

DOI: 10.5286/ISIS.E.RB2010145

ISIS Experiment Number: RB2010145

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Fabio Bruni et al; (2020): Peptides in a glassy matrix at ambient temperature: Relevance for Anhydrobiosis, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010145

Data is released under the CC-BY-4.0 license.