ISIS Neutron and Muon Source Data Journal

Chemical penetration enhancement of extracted healthy and diseased skin lipid models

Abstract: Atopic dermatitis (AD) is a multifactorial skin condition affecting up to 20% of children and 3% of adults, leading to a significant reduction in quality of life and substantial costs to the health care system. Pathologically, one of the major effects of AD is a change in the lipid composition of the intercellular lipid matrix of the stratum corneum (SC). In this experiment we aim to extend our understanding of the compositional effects on the structure of SC mimicking lipid multilayers. We will do this by simplifying the fatty acid and cholesterol components and using extracted ceramide fractions from pigskin. By studying the effect of propylene glycol, used extensively in skin formulations as penetration enhancer, we aim also to clarify its mechanism of action, and to pinpoint the SC compositional dependence of its action and of the structural integrity of the skin lipid barrier.

Principal Investigator: Dr Kathryn Browning
Experimenter: Ms Liv Sofia Elinor Damgaard
Experimenter: Professor Martin Malmsten
Local Contact: Dr Rebecca Welbourn

DOI: 10.5286/ISIS.E.RB2010458

ISIS Experiment Number: RB2010458

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Kathryn Browning et al; (2021): Chemical penetration enhancement of extracted healthy and diseased skin lipid models, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010458

Data is released under the CC-BY-4.0 license.