ISIS Neutron and Muon Source Data Journal

PROBING WATER DYNAMICS IN HEALTHY AND CANCER HUMAN TISSUE BY QENS

Abstract: Normal-to-malignant transformation, still an ill-understood process, is related to the biomechanical properties of cells within tissues, which are strongly dependent on the dynamical behaviour of interfacial water. This is known to play a fundamental role in normal cellular activity, namely through maintenance of the three-dimensional architecture and functional conformation of biopolymers.Building on the success of previous QENS and INS experiments on intracellular water in human cancer and non-tumorigenic cells [1-4], the present study aims to apply QENS for probing interfacial water dynamics in healthy and cancer human tissue. This is an innovative approach for identifying particular features associated to malignancy that may allow a better understanding of the normal-to-cancer transition thus contributing to improved cancer diagnosis methods and chemotherapeutic approaches.

Principal Investigator: Dr Maria Paula Marques
Local Contact: Dr Mona Sarter
Experimenter: Dr Ana Batista de Carvalho
Experimenter: Dr Inês Pereira dos Santos
Experimenter: Professor Luis Alberto Batista de Carvalho
Experimenter: Miss Adriana Mamede
Experimenter: Dr Victoria Garcia Sakai

DOI: 10.5286/ISIS.E.RB2010015

ISIS Experiment Number: RB2010015

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2021): PROBING WATER DYNAMICS IN HEALTHY AND CANCER HUMAN TISSUE BY QENS, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010015

Data is released under the CC-BY-4.0 license.