ISIS Neutron and Muon Source Data Journal

Small-angle neutron scattering of antimicrobial peptides

Abstract: The increase prevalence of multi-antibiotic resistant pathogens has been listed by the World Health Organisation (WHO) as one of the biggest threats to modern day healthcare and food security. As antibiotics become less effective, it is important to drive the development actives against multi-drug resistant organisms. Antimicrobial peptides (AMPs) are an attractive alternative, as they can target a range of microbes, are fast acting, and have a multi-hit strategy which decreases the chances of microbes developing resistance. We plan to do this with a SANS experiment to examine four short AMPs which have bactericidal effect of pseudomonas aeruginosa, with different bilayers based on different phases of the bacterial life-cycle, to understand the mechanisms of antimicrobial activity on the membrane, by the use of different contrasts to observe changes in peptide and lipid composition.

Principal Investigator: Dr Charlotte Jennifer Chante Edwards-Gayle
Experimenter: Dr James Doutch
Local Contact: Dr Leide Cavalcanti

DOI: 10.5286/ISIS.E.RB2000196

ISIS Experiment Number: RB2000196

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Charlotte Jennifer Chante Edwards-Gayle et al; (2021): Small-angle neutron scattering of antimicrobial peptides, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2000196

Data is released under the CC-BY-4.0 license.