ISIS Neutron and Muon Source Data Journal

Structural modification induced by Gold Nanoparticles on Lipid Bilayers

Abstract: The terapeutic efficiency and citotoxicity of inorganic nanoparticles (NP) for nanomedicine is related to NP interactions with biological interfaces like cell membranes. Synthetic model membranes are ideal platforms of controlled composition and geometry to study phenomena at the nano-bio interface. We recently investigated the interaction of the most common inorganic NP, citrated gold nanoparticles (AuNP), with synthetic lipid vesicles of different compositions, leading to their 2D aggregation on the liposomal surface. We recently performed SAXS at ESRF, finding that size and shape of AuNPs-aggregates markedly depend on the physicochemical features of the target membrane. The aim of the proposed SANS experiment is to complete the structural characterization of liposomes-AuNP hybrids, using neutrons instead of X-rays, to better highlight the lipid component of the liposomes-AuNP hybrids.

Principal Investigator: Professor Debora Berti
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Lucrezia Caselli
Experimenter: Dr Costanza Montis
Experimenter: Mr Andrea Ridolfi

DOI: 10.5286/ISIS.E.RB2010210

ISIS Experiment Number: RB2010210

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Debora Berti et al; (2021): Structural modification induced by Gold Nanoparticles on Lipid Bilayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010210

Data is released under the CC-BY-4.0 license.