ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Adsorption of Bispecific Therapeutic Monoclonal Antibodies at the Air/liquid Interface by NR
Abstract: Following our previous neutron reflection study of interfacial adsorption of a bioengineered mAb called COE-3 and its fragments, the aim of this work is to determine how the two bioengineered bispecific mAbs (COE-7, COE-8) adsorb at the air/water interface against their concentrations, pH and ionic strength. As these two mAbs are highly modified, it is important to study how their adsorption is time-dependent under different concentrations and time so that these behaviours can be compared to the native mAb. We request Inter for following the dynamic changes by exploiting its high flux beam and the time event capability.
Principal Investigator: Professor Jian Lu
Experimenter: Dr Chris van der Walle
Local Contact: Dr John Webster
Experimenter: Mr Sean Ruane
Experimenter: Dr Zongyi Li
Local Contact: Dr Mario Campana
Experimenter: Dr Mingrui Liao
DOI: 10.5286/ISIS.E.RB2010448
ISIS Experiment Number: RB2010448
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2010448-1 | SURF | 05 December 2023 | Download |
| 10.5286/ISIS.E.RB2010448-2 | SURF | 07 May 2024 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2020): Adsorption of Bispecific Therapeutic Monoclonal Antibodies at the Air/liquid Interface by NR, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010448
Data is released under the CC-BY-4.0 license.
