ISIS Neutron and Muon Source Data Journal

Evaluation of the Interaction of Propranolol Hydrochloride with Model Biomembranes

Abstract: Surfactancy effects of poorly water soluble drugs are relatively unexplored compared with their primary mode of action involving membrane transporters. Specific drug interactions with certain lipids are understood to take place at much lower drug concentrations than are needed for their primary therapeutic effect. Our interest is to characterise the structure-function relationship of a series of structurally-related drugs ? beta blockers. We have started to acquire surface pressure and ellipsometry data on the interactions of propranolol hydrochloride with model mammalian membranes. Now we require missing information from neutron reflectometry on the extent of interaction, degree of hydration and location of the drug in the model biomembranes. The data will provide the structural foundation for our project and contribute to our understanding of the role of drug-lipid interactions.

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Maxmilian Skoda
Experimenter: Miss Yixuan Yan
Experimenter: Dr Richard Campbell

DOI: 10.5286/ISIS.E.RB2010646

ISIS Experiment Number: RB2010646

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2020): Evaluation of the Interaction of Propranolol Hydrochloride with Model Biomembranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010646

Data is released under the CC-BY-4.0 license.