This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Determination of the dynamic exchange kinetics of hydrophobically trapped cyclic peptide nanotubes
Abstract: Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes (CPNTs). The conjugation of polymers to these peptides renders the resulting CPNTs water soluble, whilst providing functionality. CPNTs have promising applications as drug delivery vectors where controlled assembly and disassembly is required for tailoring drug release. In order to control the dynamic behaviour of CPNTs, we have designed and synthesised CPNTs conjugated to block copolymers with a central hydrophobic block to function as a kinetic trap. Here, we propose to use time-resolved SANS combined with isotopic contrast matching to determine the exchange kinetics of kinetically trapped peptides between hydrogenated and deuterated CPNTs. This will enable the design of CPNTs with controlled, tunable dynamics as drug delivery vectors.
Principal Investigator: Professor Sebastien Perrier
Experimenter: Miss Maria Kariuki
Experimenter: Dr Qiao Song
Local Contact: Dr Robert Dalgliesh
Experimenter: Dr Stephen Hall
DOI: 10.5286/ISIS.E.RB2010379
ISIS Experiment Number: RB2010379
Part DOI | Instrument | Public release date | Download Link |
---|---|---|---|
10.5286/ISIS.E.RB2010379-1 | LARMOR | 20 November 2023 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Sebastien Perrier et al; (2020): Determination of the dynamic exchange kinetics of hydrophobically trapped cyclic peptide nanotubes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010379
Data is released under the CC-BY-4.0 license.