ISIS Neutron and Muon Source Data Journal

Lipid membrane interactions of virus-like mesoporous silica loaded with photocatalytic TiO2 nanoparticles

Abstract: TiO2 nanoparticles (NPs) offer interesting possibilities in the context of antibiotic resistance and bacteria killing, as they are strongly antimicrobial by UV irradiation due to the generation of highly reactive oxygen species that attack the bacterial membrane. They can be loaded into mesoporous silica NPs, versatile carriers with mesopores that allow precise cargo loading and release. Here, we propose to study by neutron reflectometry the mutual structural and photooxidative effects of TiO2-loaded silica NPs, in the absence or presence of UV exposure, using anionic lipid bilayers as bacterial membrane models. We will also explore different morphologies by comparing smooth vs virus-like silica NPs, whose spikey nanotubes induce a direct mechanical action on membranes, providing novel insight into the interplay between NP topology and oxidative stress for membrane destabilization.

Principal Investigator: Professor Martin Malmsten
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Kathryn Browning
Experimenter: Dr Sara Malekkhaiat Häffner
Experimenter: Dr Elisa Maria Parra Ortiz

DOI: 10.5286/ISIS.E.RB2010363

ISIS Experiment Number: RB2010363

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Martin Malmsten et al; (2020): Lipid membrane interactions of virus-like mesoporous silica loaded with photocatalytic TiO2 nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010363

Data is released under the CC-BY-4.0 license.