ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Characterising temperature dependent morphological changes to thermosensitive semiconducting polymer nanoparticles for drug delivery
Abstract: We have synthesised a series of novel semiconducting polymer nanoparticles (SPNs) for photothermal therapy. Characterising changes to their morphology upon heating is crucial for elucidating how they can be applied to effectively deliver encapsulated cargo to cancer cells. Here we propose i) a series of experiments over a wide temperature range to capture the changes in SPN morphology upon heating, and ii) contrast matching experiments to study the intra-particle location of an encapsulated drug and its release profile. The results will provide key mechanistic insights into the application of these particles for cancer therapeutics which are not possible by other techniques.
Principal Investigator: Dr Margaret Holme
Local Contact: Dr James Doutch
Experimenter: Dr Hanna Barriga
Experimenter: Dr Adam Creamer
Experimenter: Professor Molly Stevens
DOI: 10.5286/ISIS.E.RB2010452
ISIS Experiment Number: RB2010452
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB2010452-1 | ZOOM | 02 December 2023 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Margaret Holme et al; (2020): Characterising temperature dependent morphological changes to thermosensitive semiconducting polymer nanoparticles for drug delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010452
Data is released under the CC-BY-4.0 license.
