ISIS Neutron and Muon Source Data Journal

The effect of Framework Structure, Composition and Sorbate - Framework Interactions on Controlled Anticancer Drug Release by Zeolites.

Abstract: Zeolites are a promising group of materials for use in controlled delivery systems of anticancer drugs such as 5-Fluorouracil (5-FU) as they are crystalline, relatively cheap and possess channels and cavities that are suitable for accommodating different drugs. We will use INS to probe the interactions of 5-FU upon adsorption into acidic faujasite (FAU) and beta type (BEA) zeolites, (counterion H+) whilst varying the Si/Al ratios (Si/Al = 5 and 80 for FAU, 12.5 and 360 for BEA) and thus the number of adsorption sites. We aim to observe shifts and broadenings of bands for both the zeolite hydroxyls and the 5-FU functional groups upon interaction with zeolite Brønsted acid sites. Understanding the strength of such interactions will help us gain significant insight into preliminary data from experimental release profiles, which shows faster release in zeolites with higher Si/Al ratios.

Principal Investigator: Dr Alexander O'Malley
Experimenter: Ms Katie Morton
Experimenter: Dr Paul Cox
Experimenter: Miss Sandra McHugh
Local Contact: Dr Jeff Armstrong

DOI: 10.5286/ISIS.E.RB2010380

ISIS Experiment Number: RB2010380

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Alexander O'Malley et al; (2020): The effect of Framework Structure, Composition and Sorbate - Framework Interactions on Controlled Anticancer Drug Release by Zeolites., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010380

Data is released under the CC-BY-4.0 license.