ISIS Neutron and Muon Source Data Journal

Lipid Interactions with Styrene-Maleic Acid Copolymers on Nanoparticles

Abstract: Polymer stabilized lipid nanodiscs stabilize membrane proteins for structural studies. Previously, we studied nanodisc formation using poly(styrene-maleic acid) (SMA) copolymers synthesised by RAFT techniques, which give defined weights and architectures, and also end groups that may be used for surface binding. We have shown that SMA tethered to oxide nanoparticles will solubilise lipid vesicles. By tethering SMA to relevant nanoparticle surfaces, such as conductive gold nanoparticles or super paramagnetic iron oxide nanoparticles, the applications of SMA as a membrane protein support could be broadened towards applications in electronic devices. Here, we aim to use SANS and contrast variation to determine the surface structures that develop in this system, how these compare with known SMALP nanodisc morphologies and vary with the position of the styrene block relative to the surface.

Principal Investigator: Professor Karen Edler
Experimenter: Dr Thomas Arnold
Experimenter: Ms Kerrie Morrison
Local Contact: Dr James Doutch
Experimenter: Mr George Neville

DOI: 10.5286/ISIS.E.RB2010215

ISIS Experiment Number: RB2010215

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Karen Edler et al; (2020): Lipid Interactions with Styrene-Maleic Acid Copolymers on Nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010215

Data is released under the CC-BY-4.0 license.