ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Radiation induced changes in block copolymer micelles
Abstract: Block copolymer micelles have been used to encapsulate various chemotherapeutic drugs, which can be delivered to the tumour site using the so-called Enhanced Permeation and Retention effect. However, these micelles usually release the encapsulated drugs in uncontrolled manner. There are various ways to trigger drug release by external and internal stimuli, one of which is ionizing radiation. The use of ionizing radiation as a trigger is only of interest if release can be achieved at a low radiation dose, i.e. in the order of a dose received in a diagnostic scan. For this purpose we have investigated different block copolymer systems, which can respond to radiation. In this study we want to determine any changes occuring in the self-assemblies when irradiated which lead to the osberved release.
Principal Investigator: Dr Antonia Denkova
Experimenter: Ms Huanhuan Liu
Experimenter: Dr Steven Parnell
Local Contact: Dr Robert Dalgliesh
Experimenter: Dr Jeroen Plomp
DOI: 10.5286/ISIS.E.RB1969004
ISIS Experiment Number: RB1969004
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB1969004-1 | LARMOR | 27 February 2023 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Antonia Denkova et al; (2020): Radiation induced changes in block copolymer micelles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1969004
Data is released under the CC-BY-4.0 license.
