ISIS Neutron and Muon Source Data Journal

PERFECTA ? A Superfluorinated Molecular Probe for MRI

Abstract: Magnetic resonance imaging (MRI) has had a transformative effect in modern medicine. A hot-spot imaging technique utilises another nucleus (such as 19F) to provide a second coloured layer, information which is independent to the anatomical details provided by the grey-scale proton NMR image. PERFECTA is a contrast agent which contains 36 equivalent 19F atoms and shows a single intense resonance peak. It is very stable and is easily synthesised using a one-step reaction. The hydrocarbon polar core and four ether bonds might be subject to enzymatic degradation in vivo but seems to be protected by the fluorine shell. A muSR experiment will show how resistant this shell is to protonation (modelled by mu+ implantation) and the form of the relaxation (e.g any F-mu-F signal) will reveal the implantation site and the fluorine spin relaxation as a function of temperature will be studied.

Principal Investigator: Professor Stephen Blundell
Experimenter: Dr John Wilkinson
Experimenter: Professor Tom Lancaster
Experimenter: Professor Pierangelo Metrangolo
Local Contact: Dr Francis Pratt
Experimenter: Mr George Gill

DOI: 10.5286/ISIS.E.RB2010203

ISIS Experiment Number: RB2010203

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Stephen Blundell et al; (2020): PERFECTA ? A Superfluorinated Molecular Probe for MRI, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010203

Data is released under the CC-BY-4.0 license.