ISIS Neutron and Muon Source Data Journal

How N-acyl amino acid surfactants adsorption at the air/water interface helps explaining “atypical” interaction with lipid membranes

Abstract: N-acyl amino acids are promising anionic amphiphilic molecules, which consist of a linear aliphatic chain (hydrophobic tail) and an amino-acid residue (polar head). Although they have been mainly employed in cosmetics as detergents and foaming agents, these molecules seem to be also promising for pharmaceutical applications. Anionic amphiphiles, in fact, are used as excipients in pharmaceutical technology to improve solubilisation of poorly-water soluble drugs, to increase the wettability of solid dosage forms and/or to enhance drug penetration through biological membranes.Therefore, N-acyl amino acid surfactants could represent an alternative and safer option to sulfate-based anionic surfactants (e.g sodium dodecyl sulphate, SDS). Due to the lack of information regarding toxicity concerns of these surfactants, we performed a full characterization of their physicochemical properties.

Principal Investigator: Dr Diego Romano Perinelli
Experimenter: Dr Francesco Vita
Experimenter: Professor Luca Casettari
Local Contact: Dr Mario Campana
Experimenter: Dr Michela Pisani
Experimenter: Mr Michele Verboni

DOI: 10.5286/ISIS.E.RB1920700

ISIS Experiment Number: RB1920700

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Diego Romano Perinelli et al; (2020): How N-acyl amino acid surfactants adsorption at the air/water interface helps explaining “atypical” interaction with lipid membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920700

Data is released under the CC-BY-4.0 license.