ISIS Neutron and Muon Source Data Journal

Binding studies of Quantum Dots and Pore-Forming Proteins on multi-component model cell membranes

Abstract: Cell membrane being the first line of defence of a complex cell, it forms an important scientific topic to study its encounter with various external entities. Nanoparticles are an important topic because of its applications like drug delivery. On the other hand, pore-forming proteins like listeriolysin O, present in virulent bacteria, bind to target membrane and cause cell lysis. This study aims to use Neutron Reflectivity as a powerful technique to understand the binding profile and penetration of protein/nanoparticles and the resultant modifications in molecular conformation of the different multi-component model cell membranes tuned by differently entropic and charged lipids to control the preferential binding of the charged/uncharged nanoparticles and also understand the cell lysis mechanism of the pore-forming protein LLO.

Principal Investigator: Professor Ganapathy Ayappa
Experimenter: Mrs Ilanila Ilangumaran Ponmalar
Experimenter: Professor Jaydeep Basu
Experimenter: Mr Anurag Chaudhury
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr John Webster

DOI: 10.5286/ISIS.E.RB1968069

ISIS Experiment Number: RB1968069

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Ganapathy Ayappa et al; (2020): Binding studies of Quantum Dots and Pore-Forming Proteins on multi-component model cell membranes , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1968069

Data is released under the CC-BY-4.0 license.