ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Structure of lipid monolayers following oxidative damage
Abstract: Lipids form the major component of cell membranes, which separate the contents of the cell from the external environment. The oxidation of lipids within biological membranes is implicated in a range of diseases and health effects including cancer and ageing. In this proposal we wish to examine how oxidation of specific lipids changes the structure of lipid membranes. Specifically we prepare lipid monolayers at the air-water interface containing different amounts of deuterium labeled oxidized lipids. Neutron reflection, combined with different contrasts, will be used to interrogate the lipid layers and determine the orientation and positioning of the oxidized lipids within the layer. The results will provide an enhanced understanding of how oxidative damages changes the properties of cell membranes.
Principal Investigator: Dr Katherine Thompson
Experimenter: Mr Emil Gustafsson
Local Contact: Dr Rebecca Welbourn
Experimenter: Professor Adrian Rennie
DOI: 10.5286/ISIS.E.RB1920139
ISIS Experiment Number: RB1920139
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB1920139-1 | INTER | 23 February 2023 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Katherine Thompson et al; (2020): Structure of lipid monolayers following oxidative damage, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920139
Data is released under the CC-BY-4.0 license.
