ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
SANS Investigation into the Mode of Interaction between Antibiotics and Different Model Membranes
Abstract: In this part of proposed work, we wish to explore how antibiotics minocycline and tetracycline interact with model lipid bilayers in the form of SUVs, mimicking key features of outer surfaces of red blood cells and bacteria. From home lab based dynamic light scattering and molecular dynamic simulations, we have found varying interactions associated with charges and hydrophobicity. SANS is uniquely powerful at unraveling structural details associated with antibiotic binding to the bilayers surrounding the SUVs. This work will form a useful basis for us to compare how antimicrobial peptides and traditional antibiotics interact with representative membrane bilayer models and provide valuable molecular insight of modes of actions of these compounds against different model membranes.
Principal Investigator: Professor Jian Lu
Experimenter: Dr Xuzhi Hu
Experimenter: Dr Zongyi Li
Experimenter: Professor hu zhu
Experimenter: Miss Lin Zhang
Experimenter: Mr Huayang Liu
Experimenter: Mr kangcheng shen
Experimenter: Dr Laura Fox
Experimenter: Mr KE FA
Experimenter: Miss Meixing Wang
Experimenter: Mr Peter Hollowell
Experimenter: Mr Sean Ruane
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Mingrui Liao
Experimenter: Dr Luke Clifton
Experimenter: Mr Haoning Gong
Experimenter: Dr Arwel Hughes
DOI: 10.5286/ISIS.E.RB1920459
ISIS Experiment Number: RB1920459
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB1920459-1 | SANS2D | 16 November 2022 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2019): SANS Investigation into the Mode of Interaction between Antibiotics and Different Model Membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920459
Data is released under the CC-BY-4.0 license.
