ISIS Neutron and Muon Source Data Journal

Ion and temperature effects on the self-assembly of short peptides - SANS studies

Abstract: In this work, we have selected a group of 5 short peptides I3GGHK, I4GGHK, I3GGGHK, I3GGHHK and I3KGGH to study how changes in peptide concentration, [Cu2+] and temperature affect their nanostructuring by SANS. Through extensive studies by AFM and TEM, we found that changes in GH position in the sequence can hugely affect nanostructures via altering peptide packing, layer thickness and twisting. These structural effects affect how molecules can align and form layers and extend to higher orders of structures. Because these sizes are in the order of a few nanometers and difficult to image but are ideal for SANS measurements. SANS2D is preferred because of its high structural sensitivity and wider Q range to cover different size ranges. We request 2 days of SANS2d or 4 days of LOQ to complete the work.

Principal Investigator: Professor Jian Lu
Experimenter: Dr Mingrui Liao
Experimenter: Professor hu zhu
Experimenter: Miss Lin Zhang
Experimenter: Mr Huayang Liu
Experimenter: Mr kangcheng shen
Experimenter: Dr Laura Fox
Experimenter: Mr KE FA
Experimenter: Miss Meixing Wang
Experimenter: Mr Peter Hollowell
Experimenter: Mr Sean Ruane
Experimenter: Professor Jiqian Wang
Experimenter: Dr Zongyi Li
Local Contact: Dr Robert Dalgliesh
Experimenter: Professor Hai Xu
Experimenter: Dr Xuzhi Hu

DOI: 10.5286/ISIS.E.RB1920153

ISIS Experiment Number: RB1920153

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2019): Ion and temperature effects on the self-assembly of short peptides - SANS studies, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920153

Data is released under the CC-BY-4.0 license.