ISIS Neutron and Muon Source Data Journal

Structural Observation of the Self-Assembly Kinetics of Cyclic Peptide Nanotubes

Abstract: Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes. The conjugation of polymers to these peptides renders the resulting nanotubes water soluble, whilst providing functionality. Self-assembled nanotubes have promising applications in drug encapsulation and delivery where controlled assembly and disassembly is required for tailoring drug release. We have synthesised a pH-responsive peptide which will assemble or disassemble triggered by a change in pH in different subcellular compartments. We propose to investigate the influence of both polymer chain length and drug conjugation on nanotube self-assembly kinetics and observe nanotube structural evolution using time-resolved SANS with in-line UV-vis and fluorescence spectroscopy. This will enable the optimised design of controlled, tuneable nanotubes as drug delivery vectors.

Principal Investigator: Professor Sebastien Perrier
Local Contact: Dr Robert Dalgliesh
Experimenter: Dr Najet Mahmoudi
Experimenter: Dr Qiao Song
Experimenter: Miss Maria Kariuki
Experimenter: Dr Stephen Hall
Experimenter: Miss Sophie Hill

DOI: 10.5286/ISIS.E.RB1920524

ISIS Experiment Number: RB1920524

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Sebastien Perrier et al; (2019): Structural Observation of the Self-Assembly Kinetics of Cyclic Peptide Nanotubes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920524

Data is released under the CC-BY-4.0 license.