ISIS Neutron and Muon Source Data Journal

Probing Water Structure in the Hydration layer around Poly(ethylene glycol)

Abstract: Water is the source of life, but the effects of hydration water on the conformation change and function of biological and bio-compatible macromolecules are still full of debates. Chen et al. found a dynamic transition of the solvation water at about 220 K, and claimed that such a liquid-liquid transition of water command the dynamic and function of the proteins. However, Hong and colleagues found out that dry perdeuterated protein also experience a dynamic transition at about 200 K by quasi-elastic neutron scattering. To clarify the problem, a direct observation of the structure of hydration layer about macromolecule in the transition process is crucial. Here, we propose neutron total scattering observations of dry Poly(ethylene glycol) (PEG) and PEG solvated with a single layer of water bellow and up the liquid-liquid transition of confined water at about 200 K.

Principal Investigator: Dr He Cheng
Experimenter: Mr SONGWEN XIAO
Experimenter: Dr Taisen Zuo
Local Contact: Dr Tristan Youngs
Experimenter: Dr Guisheng Jiao
Experimenter: Dr CHANGLI MA
Experimenter: Mr XIONG LIN

DOI: 10.5286/ISIS.E.RB1920314

ISIS Experiment Number: RB1920314

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr He Cheng et al; (2019): Probing Water Structure in the Hydration layer around Poly(ethylene glycol), STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920314

Data is released under the CC-BY-4.0 license.