ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Monolayer behaviour of DMPC and DEHP with cholesterol
Abstract: Donated blood is typically stored in bags made of PVC plasticized with DEHP. DEHP migrates into the blood and the amount in the blood cells can be 5 to 10% of the phospholipid content. This stabilizes the membranes of red blood cells and increases the shelf life of stored blood. DEHP is toxic and a non-toxic alternative is desired. We now plan to extend previous studies on a two-component system of the lipid, DMPC with DEHP by adding cholesterol. We will investigate the role of DEHP in a system with more relevant composition where it causes different behaviour. Monolayers will be investigated at an air-water interface using specular reflectivity. Insights into stabilization will lead to greater understanding of how to preserve blood cells and increase the storage life of donated blood.
Principal Investigator: Professor Adrian Rennie
Local Contact: Dr Rebecca Welbourn
Experimenter: Dr Maja Hellsing
Experimenter: Dr Tim Bowden
Experimenter: Mr Emil Gustafsson
Experimenter: Miss Karolina Mothander
DOI: 10.5286/ISIS.E.RB1920287
ISIS Experiment Number: RB1920287
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.RB1920287-1 | INTER | 22 October 2022 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Adrian Rennie et al; (2019): Monolayer behaviour of DMPC and DEHP with cholesterol , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920287
Data is released under the CC-BY-4.0 license.
