ISIS Neutron and Muon Source Data Journal

Membrane interactions of virus-like silica nanoparticles as antimicrobial peptide carriers

Abstract: As a result of an increasing number of bacteria developing resistance against antibiotics, antimicrobial peptides (AMPs) are currently attracting significant interest. However, much less focus has been placed on delivery systems for AMPs. Nanoparticles may provide opportunities, e.g., for controlling peptide release, reducing infection-related AMP degradation or increasing bioavailability. We have previously shown that mesoporous silica nanoparticles (MSNP) are interesting delivery systems for AMPs, e.g., providing protection against proteolytic degradation. We propose to extend this work by addressing the effect of particle topography on membrane interactions and antimicrobial effects of MSNPs. In this proposal we plan to compare interactions of ’virus-like’ and smooth MSNPs with negative charged POPC/POPG bilayers as bacterial membrane mimics, both in the absence and presence of AMP.

Principal Investigator: Professor Martin Malmsten
Experimenter: Dr Sara Malekkhaiat Häffner
Experimenter: Dr Kathryn Browning
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Elisa Maria Parra Ortiz
Experimenter: Ms Liv Sofia Elinor Damgaard

DOI: 10.5286/ISIS.E.RB1920384

ISIS Experiment Number: RB1920384

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Martin Malmsten et al; (2019): Membrane interactions of virus-like silica nanoparticles as antimicrobial peptide carriers , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920384

Data is released under the CC-BY-4.0 license.