ISIS Neutron and Muon Source Data Journal

Hyaluronic acid-based nanogels encapsulating cell-penetrating peptides and insulin

Abstract: In this proposal we want to characterize the physico-chemical properties of self-assembling nanogels composed of octenyl-succinic anhydride modified hyaluronic acid (OSA-HA) encapsulating cell-penetrating peptides (CPPs). CPPs are short amino acid chains (10-50 AAs) which have shown to enhance transport of cargos, such as insulin into or across cells. We have assessed the formation of nanogels with a lipophilic antibiotic and an antimicrobial peptide and have noticed a difference in structural organization, but we still lack fundamental understanding on what causes the changes in the structure of the nanogels upon drug loading. We would like to use a range of 12 peptides - from more cationic to neutral and more hydrophilic to more hydrophobic - for nanogel formulation and assess the changes in nanogel structure as a result of peptide charge and hydrophobicity.

Principal Investigator: Professor Hanne Mørck Nielsen
Local Contact: Dr Steve King
Experimenter: Miss Ragna Guldsmed Diedrichsen
Local Contact: Dr Leide Cavalcanti
Experimenter: Dr Sylvia Klodzinska

DOI: 10.5286/ISIS.E.RB1920382

ISIS Experiment Number: RB1920382

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Hanne Mørck Nielsen et al; (2019): Hyaluronic acid-based nanogels encapsulating cell-penetrating peptides and insulin, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920382

Data is released under the CC-BY-4.0 license.