ISIS Neutron and Muon Source Data Journal

Bacterial lipoteichoic-acid (LTA) micelles: From molecular self-assembly to mediating septic shocks

Abstract: Whilst the biological effect of lipoteichoic-acid (LTA) contributing to bacterial infections is widely reported in microbiological and immunological studies, very little is understood on a physicochemical level; for instance, the amphiphilic nature of LTA would drive its self-assembly into different aggregates such as micelles and liposomes, which would be directly relevant to how it mediates interactions with biological surfaces, biofilm formation, and consequent septic shocks. We propose a first SANS study of the self-assembled structure (size, shape, and aggregation number) of LTA micelles (with a reported critical micelle concentration ~ 2-5 µg ml-1) extracted from Bacillus Subtilis at different concentrations (2-1000 µg ml-1) and temperatures (25-45 oC), as well as different ionic strengths using mono-/di-/tri-valent cations.

Principal Investigator: Professor Wuge Briscoe
Experimenter: Dr Sarah Rogers
Experimenter: Miss Holly Stockdale
Experimenter: Miss Lauren Matthews
Experimenter: Dr Bhaveshkumar Narendrabhai Bharatiya
Experimenter: Mr Gang Wang
Experimenter: Miss Charlotte Kenton

DOI: 10.5286/ISIS.E.RB1920280

ISIS Experiment Number: RB1920280

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Wuge Briscoe et al; (2019): Bacterial lipoteichoic-acid (LTA) micelles: From molecular self-assembly to mediating septic shocks, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920280

Data is released under the CC-BY-4.0 license.