ISIS Neutron and Muon Source Data Journal

This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.


Structural stability of novel anticancer hexameric fusion protein: SANS investigation

Abstract: A shift towards antibody-based cancer treatments has occurred due to their ability to provide targeted cancer treatment with fewer negative side effects than traditional chemotherapy or radiotherapy. Large antibody fusions with proteins that activate the human immune system to combat tumours have been developed with potent anti-tumour responses observed in preclinical models. The structure of a protein is key to understanding its function so we propose to study the shape, size and finer structure of a large fusion protein specifically designed to enable the immune system to destroy cancerous tissue. At its first ever SANS study, we will investigate how environmental conditions such as pH, temperature and salt concentration impact the structure of the aforementioned fusion protein. Understanding protein structure is vital in understanding why a protein is able to function.

Principal Investigator: Professor Jian Lu
Local Contact: Dr Steve King
Experimenter: Dr Zongyi Li
Experimenter: Mr kangcheng shen
Experimenter: Mr Peter Hollowell
Local Contact: Dr Leide Cavalcanti
Experimenter: Dr Chris van der Walle

DOI: 10.5286/ISIS.E.RB1920290

ISIS Experiment Number: RB1920290

Part DOI Instrument Public release date Download Link
10.5286/ISIS.E.RB1920290-1 SANS2D 18 October 2022 Download

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2019): Structural stability of novel anticancer hexameric fusion protein: SANS investigation, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920290

Data is released under the CC-BY-4.0 license.



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